1、No study reported a clinically important reduction (> 50%) in apnea.
2、The use of clinically important end points would strengthen the validity of study outcomes.
3、But many patients who receive CRT according to those criteria don't improve clinically, suggesting they didn't have clinically important dyssynchrony to begin with.
4、Whilst there were small improvements in pain, disability, fatigue and depression, the improvements were not clinically important.
5、Conclusions The frequency of clinically important valve regurgitation was significantly increased in patients taking pergolide or cabergoline, but not in patients taking non– ergot-derived dopamine agonists, as compared with control subjects.
